综合泛癌分析和乳腺癌验证确定BEND3作为潜在的预后和免疫生物标志物
Yuting Gou1, Yongxiang Li1, Yiyang Wang1
1Department of Breast Surgery, Center of Digestive and Vascular, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, People's Republic of China.
Breast cancer (Dove Medical Press)
|January 7, 2026
概括
这项研究表明,BEND3在许多癌症中过度表达,并与预后不佳有关. BEND3促进癌细胞的增殖和入侵,表明其作为预后生物标志物的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 尽管已知BEND3在染色质和细胞循环调节中的作用,但BEND3在癌症中的功能尚不清楚.
- 了解BEND3的作用对于识别新的癌症生物标志物和治疗点至关重要.
研究的目的:
- 对BEND3的临床相关性进行全面的泛癌症分析,并探索其在癌症中的分子机制.
- 研究BEND3在乳腺癌细胞系中的致癌作用.
主要方法:
- 利用公共数据库 (UCSC Xena,TCGA,GTEx,GEO) 对BEND3遗传变异,CNV和甲基化进行泛癌分析.
- 通过IHC,WB和qRT-PCR评估了BEND3的表达;使用CCK-8,殖民地形成和乳腺癌细胞中伤口愈合分析,评估了它在扩散,迁移和入侵中的作用.
主要成果:
- 在多种癌症 (如乳腺癌,肝癌,肺癌) 中,BEND3经常过度表达,并与预后不佳有关.
- BEND3的表达与瘤突变负担,微卫星不稳定性,免疫检查点和免疫透相关.
- 实验室研究证实,BEND3过度表达促进乳腺癌细胞的增殖,迁移和入侵,而淘汰抑制这些表型.
结论:
- 由于BEND3的过度表达,与生存率差的关联以及瘤免疫中的作用,BEND3是癌症中潜在的预后和免疫相关的生物标志物.
- BEND3表现出致癌功能,并可能调节关键的癌症途径,因此需要进一步研究其机制和治疗潜力.
更多相关视频
07:41Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
9.4K
07:47Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
2.1K
相关概念视频
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...