冷微波真空干燥优化了Pyracantha fortuneana水果多糖的结构和双重抗糖尿病活性
Juyan Sun1, Xiuping Wan1, Meiwen Sun1
1College of Food Science and Engineering, Guiyang University, Guiyang, Guizhou 550005, PR China.
Food chemistry: X
|January 7, 2026
概括
冷-微波-真空干燥 (FMVD) 优化了Pyracantha fortuneana水果多糖体 (PFPs) 用于糖尿病管理. FMVD增强了PFP产量,尿酸含量和生物活性,提供卓越的抗高血糖和抗糖化作用.
科学领域:
- 食品科学与技术 食品科学与技术
- 生物化学 生物化学
- 营养保健品 营养保健品
背景情况:
- 干燥方法显著影响水果多糖的结构和功能.
- 不同的干燥模式对Pyracantha fortuneana水果多糖体 (PFPs) 的特定影响及其抗糖尿病特性尚不清楚.
研究的目的:
- 为了比较六种可扩展的干燥方法 (自然,热空气,红外线,冷干燥,微波真空和冷微波真空干燥) 对它们对PFP产量,结构和抗糖尿病生物活性的影响.
- 建立PFP的定量结构-活动关系,以指导糖尿病管理功能成分的开发.
主要方法:
- 对Pyracantha fortuneana水果进行了六种干燥方法.
- 分析了多糖的产量,尿酸含量,重量平均分子量,结晶性和热稳定性.
- 实验室试验用于评估α-葡萄糖酶抑制和梅拉德反应的减弱 (果糖胺的形成和先进的糖化最终产品生成).
- 使用了多变量相关性,动力学和光谱学分析.
主要成果:
- 冷微波真空干燥 (FMVD) 产生了最高的多糖含量 (6.22%) 和尿酸 (45.48%).
- FMVD导致了分子量较低的PFP,结晶性降低,热稳定性提高.
- PFP-FMVD表现出最强的α-葡萄糖酶抑制 (IC50 = 0.51 mg/mL) 和最有效的抑制果糖胺形成 (62.27%在8 mg/mL) 和AGEs (IC50 = 3.48 mg/mL).
结论:
- FMVD是最有效的干燥策略,可以优化PFP结构并增强其双重抗高血糖和抗糖化活性.
- 较高的银河酸/酸含量和较低的分子量是改善生物活性的关键结构特征.
- 这项研究为设计用于糖尿病管理的功能性多糖化合物成分提供了机制性见解.
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