上肢与下肢狂肌肉瘤存活率的比较:一个SEER数据库分析分析
Connor J Tupper1,2, Laura M Cogua2, Harvey Y Wang2
1Department of Orthopedic Surgery, Hofstra/Northwell Health Zucker School of Medicine, Long Island Jewish/North Shore University, New Hyde Park, NY, United States.
概括
肢体狂肌肉瘤 (RMS) 的生存率显示,上肢 (UE) 的RMS比下肢 (LE) 的RMS有更好的一年生存率. 然而,经过调整的分析显示,UE和LE RMS之间整体存活率没有显著差异.
科学领域:
- 在瘤学瘤学.
- 儿科瘤学 儿科瘤学
- 手术瘤学手术瘤学
背景情况:
- 由于诸如膜组织学,转移和淋巴结干扰等因素,四肢肌肉肉瘤 (RMS) 的预后不佳.
- 基于人口的有限数据存在,比较上肢 (UE) 和下肢 (LE) 之间的生存结果.
- 了解预后差异对于优化极端RMS治疗策略至关重要.
研究的目的:
- 为了比较上肢 (UE) 和下肢 (LE) 的生存结果,拉布多米索尔科马 (RMS).
- 根据四肢RMS的主要部位来确定预后的潜在差异.
- 为有限的现有文献提供数据,关于UE与LE RMS存活率.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库来识别2000-2020年间诊断的UE和LE RMS病例.
- 进行了一年和五年生存率的描述性统计和千平方分析.
- 进行了日志等级和考克斯回归分析,以比较UE和LE RMS队列之间的生存率.
主要成果:
- 总共分析了641例RMS病例:221例 (34.5%) 是UE和420例 (65.5%) 是LE.
- 在Log-rank测试中,与LE RMS (81.4%) 相比,UE RMS (88.7%) 的一年生存率明显更长 (p=0.020).
- 五年生存率相似,考克斯回归分析显示,UE和LE RMS (HR=1.172,p=0.322) 之间的整体生存率没有显著差异.
结论:
- 虽然上肢 (UE) 轮骨髓瘤 (RMS) 显示出更高的一年生存率,但这种差异在调整后的分析中没有持续.
- 在考虑其他因素时,在UE和LE RMS之间没有发现总生存时间的显著差异.
- 未来的前性研究应该包括UE和LE RMS的直接比较,以进一步阐明预后因素.
更多相关视频
07:13Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
Published on: April 18, 2025
482
07:31A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
Published on: May 3, 2021
4.2K
相关概念视频
01:21Cancer Survival Analysis
645
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
645
01:20Comparing the Survival Analysis of Two or More Groups
548
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
548
01:24Kaplan-Meier Approach
556
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
556
01:03Rous Sarcoma Virus (RSV) and Cancer
6.2K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.2K
01:20Actuarial Approach
284
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
284