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Updated: Jan 13, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

基于转录基因组的模型用于预测HNSCC患者的放射治疗反应.

Tomasz Kolenda¹, Piotr Białas², Alicja Braska³

¹Laboratory of Cancer Genetics, Greater Poland Cancer Centre, Poznan, Poland.

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

|January 7, 2026

概括

此摘要是机器生成的。

这项研究确定了抗放射治疗的头部和部状细胞癌 (HNSCCs) 的分子差异. 没有有效治疗的患者显示DNA修复基因表达增加,这表明放射电阻的潜在生物标志物.

关键词:

在RNA测序过程中,RNA测序在TCGA中,TCGA就是TCGA.个性化医疗是个性化的医疗.辐射疗法辐射疗法转录组 (transcriptome) 是一个转录组.

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科学领域:

在瘤学瘤学.
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

头部和部状细胞癌 (HNSCCs) 主要通过手术和放射治疗来治疗.
瘤异质性和微环境影响放射治疗的成功,导致放射电阻.
在HNSCC中放射电阻的机制尚未完全理解,这在瘤学中构成了挑战.

研究的目的:

为了研究HNSCC有效和无效放射治疗结果的患者之间的分子差异.
在HNSCC中识别与放射治疗反应相关的潜在生物标志物.

主要方法:

来自癌症基因组图谱项目 (TCGA) 的放射治疗的HNSCC患者的回顾性分析.
排除患有HPV感染,化疗或向治疗的患者.
使用基因组丰富分析 (GSEA) 的临床病理和转录组数据 (RNAseq) 的比较.

主要成果:

确定了两个组:有效治疗组 (ETG,n=34) 和无效治疗组 (ITG,n=31).
与ETG患者相比,ITG患者的无进展间隔 (PFI) 显著较短 (中位数为266天,p < 0.0001).
分子分析显示,ITG组中DNA修复基因的表达显著增加.

结论:

在HNSCC中开发了一种分子独特的放射治疗反应模型.
基因表达的差异,特别是DNA修复途径的差异,是放射电阻的特征.
这些发现表明,该模型对于识别HNSCC放射电阻的生物标志物具有潜在的实用性.