在左乳腺癌患者接受低分离放射治疗的患者中,晚期心脏影响
Budhi Singh Yadav1, Ashwani Sood2, Divya Dahiya3
1Radiotherapy and Oncology, PGIMER, Chandigarh, India.
概括
对左侧乳腺癌的低分离放射治疗显示出大多是轻微的心脏效应. 中度心脏问题与中心肺部距离有关,观察到最小的左心室功能障碍.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
背景情况:
- 评估为左侧乳腺癌治疗的患者晚期心脏影响.
- 专注于低分离放射治疗作为一种治疗方式.
研究的目的:
- 分析左侧乳腺癌的低分离放射治疗后的晚期心脏影响.
- 调查心肌输液缺陷 (MPD) 的发生率和特征.
主要方法:
- 包括87名患者治疗左侧乳腺癌的放射治疗 (35-40 Gy/15-16#/3周) 至少10年前.
- 利用心声回声和压力心肌 perfusion scintigraphy (MPS) 来检测MPDs. 使用心声回声和压力心肌 perfusion scintigraphy (MPS) 来检测MPDs.
- 定义了MPD的程度和严重程度,并分析了与临床因素的关联,如中心肺部距离 (CLD).
主要成果:
- 36%的患者 (31/87) 呈现MPD,主要轻度 (28%) 位于左心室顶部.
- 中度和固定的MPD与CLD≥2.5厘米 (p = 0.027) 有意义地相关.
- 左心室喷射分数恶化仅发生在6%的患者中,4.5%的患者经历了冠状动脉事件.
结论:
- 对左侧乳腺癌的低分离放射治疗通常会导致轻微的心脏影响.
- 中心肺距离≥2.5厘米是中度至重度MPD的预测指标.
- 在这种治疗方案后,左心室功能显著下降是罕见的.
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