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在孕前和与心脏代谢风险相关的循环MALAT1

Tove Lekva¹, Monica Frøystad^1,2, Annika E Michelsen^1,2

¹Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Norway. (T.L., M.F., A.E.M., Y.K., P.A., B.H., T.U.).

Hypertension (Dallas, Tex. : 1979)

|January 7, 2026

概括

孕前与孕妇MALAT1RNA水平较低有关. 这些降低的MALAT1和NEAT1水平在怀孕后持续存在,并与心血管疾病风险有关.

科学领域:

产科和妇科产科和妇科
心血管疾病研究研究
分子生物学分子生物学

背景情况:

孕前会影响2-8%的怀孕,并增加了心血管疾病的风险,在妇女有病史的条件.
长非编码RNA MALAT1 调节与心血管疾病相关的炎症反应.
在孕前的胎盘中,MALAT1水平下降,可能会影响附近的RNA表达.

研究的目的:

在患有和没有产前的妇女中研究MALAT1,NEAT1,mascRNA,SCYL1和FRMD8的表达.
为了评估这些RNA与心脏代谢风险标志物的关联,在有先兆子史的妇女中.
探索MALAT1在与妊娠前和心血管疾病相关的炎症反应中的功能作用.

主要方法:

在外周血液单核细胞和血/细胞外囊中评估了MALAT1,NEAT1,mascRNA,SCYL1和FRMD8的表达.
在怀孕期间 (STORK队列) 和5年随访期间从健康和孕前妇女收集样本.
在体中对分化巨细胞中的MALAT1进行沉默,以评估其对炎症标志物的影响.

主要成果:

在妊娠前期间,外周血液单核细胞中MALAT1,NEAT1,mascRNA和FRMD8的含量下降.
在有孕前史的女性中,外周血液单核细胞中MALAT1和NEAT1的随访水平降低,并与心脏代谢标记物相关.
抑制巨细胞中的MALAT1会增加IL-6的分泌,并降低MMP9和VEGF-A水平.

结论:

周围血液单核细胞中MALAT1和NEAT1的降低与怀孕期间和随访期间的孕前有关.
这些RNA转录显示了与心脏代谢风险标志物的关联,在有先兆子史的女性中.
马拉特1和邻近的RNAs可以作为潜在的治疗点来管理子宫前和相关的心脏代谢风险.

关键词:

心血管疾病心血管疾病内皮细胞是内皮细胞.白细胞,单核细胞.巨细胞是什么?巨细胞是什么?孕产妇产前症 (pre-eclampsia) 是一个疾病.

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