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导航药物动力学:释放芯片上的药理动力学和药理动力学

Anish Kumar Das¹, Rakesh Mutukuri¹, Neelanjan Chowdhury¹

¹Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER) Kolkata, Chunilal Bhawan, Maniktala, Kolkata, 700054, West Bengal, India.

Drug metabolism and bioanalysis letters

|January 7, 2026

概括

器官在芯片 (OoC) 技术提供了一种可靠的体外方法,用于预测药物的吸收,分布,新陈代谢,分泌和毒性 (ADMET). 这种方法克服了传统临床前研究的局限性,改善了药物发现和开发.

科学领域:

药理学药理学是指药理学的学科.
生物技术是生物技术.
药物发现药物发现药物发现

背景情况:

吸收,分布,新陈代谢,分泌和毒性 (ADMET) 分析的传统体外和体内方法面临着细胞参数缺失和物种间变异性的挑战.
这些局限性导致临床试验中临床前结果的可复制性较差,阻碍了药物发现和开发.
有必要进行可靠的体外药理动力学-药理动力学 (PK-PD) 研究.

研究的目的:

审查器官芯片 (OoC) 技术在药理动力学-药理动力学 (PK-PD) 研究中的应用和范围.
突出 OoC 作为可靠的 in vitro PK-PD 分析的有希望的解决方案.
为这个领域的未来研究提供见解.

主要方法:

在PK/PD研究中对芯片上器官 (OoC) 技术应用的审查.
对OOC克服传统ADMET分析的局限性潜力的分析.
专注于OoC作为一种体外技术,可以产生可靠的PK/PD结果.

主要成果:

器官在芯片 (OoC) 技术为ADMET分析提供了一种新的体外方法.
OoC系统可以产生可靠的PK/PD结果,解决传统方法的局限性.
该技术显示了提高临床前药物评估的准确性和可重复性的巨大潜力.

结论:

器官在芯片 (OoC) 技术是PK-PD体外研究的宝贵工具.
OoC提供了一个比传统的临床前ADMET方法更可靠和可复制的替代方案.
这次审查支持OOC作为推动药物发现和开发的关键技术.

关键词:

器官在芯片上的器官的PK-PD参数.药物发现. 药物发现.跨物种变异性的变化.微生理系统的微生理系统多器官芯片多器官芯片

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