Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Methods of Medium Optimization01:28

Methods of Medium Optimization

Optimizing growth media enhances microbial proliferation and maximizes product yield. Statistical experimental design methodologies provide structured and reproducible approaches, offering progressively higher levels of robustness and efficiency.The One-Factor-at-a-Time (OFAT) MethodThe One-Factor-at-a-Time (OFAT) method involves adjusting a single variable while keeping all others constant. However, it cannot detect interactions between variables, often leading to suboptimal outcomes when...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

History of infertility, risk of type 2 diabetes and HbA<sub>1c</sub> levels in the Nurses' Health Study II.

Diabetologia·2026
Same author

High-resolution metabolomics of maternal polybrominated diphenyl ethers (PBDE) exposure and preterm birth in the Atlanta African American Maternal-Child Cohort.

Communications medicine·2026
Same author

Differential DNA methylation in blood as potential mediator of the association between ambient PM<sub>2.5</sub> and cerebrospinal fluid biomarkers of Alzheimer's disease among a cognitively normal population-based cohort.

Molecular psychiatry·2026
Same author

Association between maternal organophosphate esters metabolite levels during pregnancy and internalizing and externalizing behaviors in children at 2-5 years.

Environmental epidemiology (Philadelphia, Pa.)·2026
Same author

Trajectories of reproductive events from menarche to menopause: identifying patterns and differences by childhood maltreatment and socioeconomic position.

American journal of epidemiology·2026
Same author

Disinfection Byproducts, Oxidative Stress, and Sleep Quality among Healthy Chinese Men.

Environment & health (Washington, D.C.)·2026
Same journal

Correction to "Marine Scrubbers vs Low-Sulfur Fuels: A Comprehensive Well-To-Wake Life Cycle Assessment Supported by Measurements Aboard an Ocean-Going Vessel".

Environmental science & technology·2026
Same journal

Emissions and Cost Trade-Offs of Time-Matched Clean Electricity Procurement under Interannual Weather Variability: A Case Study of Hydrogen Production.

Environmental science & technology·2026
Same journal

Divergent Thermal Feedbacks of Urbanization and Greening Modulate the Urban Heat Island in 21st-Century China.

Environmental science & technology·2026
Same journal

Friction-Mediated Transfer of Low Molecular Weight Chemicals from Consumer Mats to Fabrics: Insights for Dermal Exposure.

Environmental science & technology·2026
Same journal

Molecular Drivers of Contrasting Photoreactivity in Extracellular versus Intracellular Organic Matter from Chlorophyta and Cyanobacteria.

Environmental science & technology·2026
Same journal

Effective Precipitate Cleaning with a Reversible Flow Cell Sustains Stable Energy Intensity for Oceanic CO<sub>2</sub> Removal.

Environmental science & technology·2026
查看所有相关文章

相关实验视频

Updated: May 11, 2026

A Strategy for Sensitive, Large Scale Quantitative Metabolomics
14:18

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

21.6K

在代谢学数据中对高维度调解的评估方法

Susan S Hoffman1, Donghai Liang1,2, Anne Dunlop3

  • 1Department of Epidemiology, Emory University, Atlanta, Georgia 30322, United States.

Environmental science & technology
|January 7, 2026
PubMed
概括
此摘要是机器生成的。

高维介导分析方法 (HIMA,HDMA) 和中途相遇 (MITM) 被评估为代谢学数据. HDMA准确估计了总间接影响,而HIMA显示出有希望的结果,建议采取平行方法来获得可靠的结果.

关键词:
这是一个HDMA HDMA.希玛 (HIMA) 是一个高维度调解的调解方式在中间相遇.代谢生物组的代谢生物组模拟模拟是指一个模拟模拟.

更多相关视频

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis
07:11

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Published on: November 10, 2023

3.2K
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

1.0K

相关实验视频

Last Updated: May 11, 2026

A Strategy for Sensitive, Large Scale Quantitative Metabolomics
14:18

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

21.6K
Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis
07:11

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Published on: November 10, 2023

3.2K
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

1.0K

科学领域:

  • 代谢学 代谢学 代谢学
  • 统计遗传学 统计遗传学
  • 生物信息学是一种生物信息学.

背景情况:

  • 代谢学中的高维数据对调解分析提出了挑战.
  • 像HIMA和HDMA这样的现有方法需要对准确性和可扩展性进行评估.
  • 了解间接影响对于阐明生物途径至关重要.

研究的目的:

  • 为了比较高维度调解分析方法 (HIMA,HDMA) 和"相遇在中间" (MITM) 方法的性能.
  • 评估估计总间接影响 (TIE) 和组件间接影响 (CIE) 的准确性.
  • 在各种模拟场景中评估灵敏度和特异性.

主要方法:

  • 模拟的代谢学数据具有不同的样本大小,调解器集大小和相关性结构.
  • 对HIMA (等) 的评价 和HDMA (Gao等人) 的使用. 用于估计TIE和CIEs.
  • 评估中途会议 (MITM) 方法及其绩效指标.

主要成果:

  • 在独立的代谢物场景中,HDMA提供了最准确的TIE估计;HIMA也显示了可靠的CIE估计.
  • MITM通常低估了TIE; HIMA的TIE估计随着更大的调解效应大小而有所改善.
  • 在相关的设置中,CIE估计是不可行的,所有方法都低估了TIE;随着效应和样本大小较小,灵敏度下降.

结论:

  • HIMA提供准确的调解结果,但可能会减少维度,可能会排除特征.
  • 建议应用并行调解方法 (MITM,HIMA) 并关注重叠的结果.
  • 需要强大的,可扩展的调解方法,特别是针对非目标代谢学数据.