Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Autoimmune Disorders01:29

Autoimmune Disorders

1.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.4K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.2K
What is the Immune System?01:38

What is the Immune System?

126.5K
Overview
126.5K
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

1.2K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.2K
Teeth01:15

Teeth

1.6K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
1.6K
T Cell Types and Functions01:24

T Cell Types and Functions

2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Genetic determinants of drug-induced gingival overgrowth.

Scientific reports·2026
Same author

Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease.

Journal of periodontology·2025
Same author

Multi-Omics Signatures of Periodontitis and Periodontal Therapy on the Oral and Gut Microbiome.

Journal of periodontal research·2025
Same author

N-acyl homoserine lactone signaling modulates bacterial community associated with human dental plaque.

NPJ biofilms and microbiomes·2025
Same author

Female Mice Lacking LSD1 in Myeloid Cells Are Resistant to Inflammatory Bone Loss.

Cells·2025
Same author

Accuracy of Metabolomics in Peri-Implant Crevicular Fluid for Diagnosis and Prognosis of Peri-Implantitis.

Journal of periodontal research·2025

相关实验视频

Updated: Jan 13, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

12.2K

自免疫性和牙周炎.

Massimo Costalonga1, Vivek Thumbigere-Math2, Mark C Herzberg1

  • 1Division of Basic Sciences, Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA.

Journal of periodontal research
|January 7, 2026
PubMed
概括
此摘要是机器生成的。

系统性自身免疫发生在免疫耐受性失败时,导致自我反应的T细胞和B细胞攻击宿主组织. 牙周炎加剧了这种情况,通过促进素和表皮质的扩散,激活休眠的自身反应细胞和驱动自身免疫性疾病.

更多相关视频

Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

12.8K
Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

19.8K

相关实验视频

Last Updated: Jan 13, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

12.2K
Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

12.8K
Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

19.8K

科学领域:

  • 免疫学 免疫学 免疫学
  • 这是一种自身免疫力.
  • 牙周病是牙周病的一种疾病.

背景情况:

  • 自免疫性是由于免疫耐受性失败而产生的,允许自我反应性淋巴细胞攻击宿主组织.
  • 牙周炎涉及炎症和蛋白质修饰,可以触发或恶化自身免疫性疾病.

研究的目的:

  • 审查将牙周炎与系统性自身免疫性联系起来的免疫机制.
  • 解释牙周病原生物如何促进自身免疫性疾病的发展和恶化.

主要方法:

  • 这篇叙事综述综合了目前关于免疫耐受性,T和B细胞激活以及自身免疫的翻译后修改的证据.
  • 它检查了牙周病原体如 Porphyromonas gingivalis 在启动和放大自身免疫反应中的作用.

主要成果:

  • 在牙周炎期间,休眠的自反应性T细胞可以被修改的自我抗原或微生物激活.
  • 牙周炎促进了素和表皮质的扩散,扩大了自身免疫反应.
  • 牙周病原生物通过分子模仿和炎症促进系统性自身免疫.

结论:

  • 牙周炎不仅会导致局部组织破坏,还会导致全身性自身免疫.
  • 在牙周炎中,诸如素化和表皮质扩散等机制可以启动或加剧自身免疫性疾病,如类风湿性关节炎,IBD和AD.