在甲状腺切除术后的长期卡尔西托尼因肌甲状腺癌在MEN2A中产生
Marijn L van den Berg1, Dirk-Jan van Beek1, Medard F M van den Broek2
1Department of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Endocrine-related cancer
|January 7, 2026
概括
对于多发性内分泌新陈代谢2A型 (MEN2A) 患者来说,甲状腺切除术后 (TTx) 无法检测到的素水平通常仍然很低. 这表明,在没有髓性甲状腺癌 (MTC) 和TTx后无法检测到的色素的MEN2A患者中,可能不需要进行生化随访.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 手术瘤学手术瘤学
背景情况:
- 甲状腺切除术是2A型多发性内分泌瘤瘤 (MEN2A) 的标准治疗方法.
- 甲状腺切除术后的卡尔西托尼监测是MEN2A患者的指导方针建议的.
- 在MEN2A中全甲状腺切除术 (TTx) 后,色素水平的自然进展需要进一步阐明.
研究的目的:
- 在被诊断为多发性内分泌新陈代谢2A型 (MEN2A) 患者的全甲状腺切除术 (TTx) 后,调查素水平的长期趋势.
- 为了将术后的卡尔西托宁水平与病原学和手术方法 (预防性与非预防性TTx) 相关联.
主要方法:
- 在1993年至2019年期间接受TTx的MEN2A患者的回顾性分析.
- 纳入标准:多次手术后测量色素.
- 序列卡尔西托尼,临床结果,组织病理学和TTx类型的相关性.
主要成果:
- 52名MEN2A患者接受了TTx;29人患有髓性甲状腺癌 (MTC).
- 38名患者在第一次术后没有检测到色素,32名患者长期没有检测到色素.
- 持续的MTC或复发发生在6名患者中,所有患者都患有MTC,可检测的第一个术后色素和非预防性TTx.
结论:
- 在MEN2A患者中,在TTx后,术后不可检测的色素水平通常维持.
- 对于没有MTC和无法检测到的初始术后色素的MEN2A患者,生化随访可能不必要.
- 在MEN2A中早期的预防性TTx与持续的无法检测到的激素水平有关.
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