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Updated: Jan 13, 2026

Basophil Activation Test for Allergy Diagnosis

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Published on: May 31, 2021

血清哈普特蛋白作为慢性自发性疹患者治疗反应的预测因子

Kun-Woo Park¹, Boyoun Choi¹, Da-Hye Moon¹

¹Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Republic of Korea.

Clinical and translational allergy

|January 7, 2026

概括

在慢性自发性疹 (CSU) 中血清哈普托格洛宾 (HP) 升高,并且随着治疗而降低. 较高的基线HP水平独立地预测了CSU的完全控制,建议将其用作预后生物标志物.

科学领域:

免疫学免疫学免疫学
生物化学生物化学

背景情况:

慢性自发性疹病 (CSU) 是一种由巨细胞驱动的疾病,与全身炎症有关.
球蛋白 (HP) 具有免疫调节作用,而松素影响表皮屏障功能.

研究的目的:

在CSU患者中调查血清HP和zonulin的临床相关性.
评估HP和zonulin与CSU治疗结果的关联.

主要方法:

使用ELISA测量了124名CSU患者和57名健康对照者的血清HP和zonulin水平.
在治疗3个月后收集后续样本,以评估UAS7和UCT等临床结果.

主要成果:

与对照组相比,CSU患者的血清HP水平显著更高; zonulin水平没有差异.
治疗后血清HP显著下降,特别是在症状明显改善的患者中.
升高的基线HP独立预测完全控制了疹,截止值≥1249μg/mL.

结论:

血清HP在CSU患者中升高,其水平在有效治疗下降.
惠普作为一个潜在的预后生物标志物用于预测CSU患者的完全控制.

关键词:

慢性自发性疹完整的控制,完全的控制.哈普托格洛宾 (haptoglobin) 是一种蛋白质.这里是 zonulin zonulin 的位置.

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Hypersensitivities

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