Jove
Visualize
联系我们

相关概念视频

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

SIRT5 acts in the tumor microenvironment via endothelial cell metabolism to support breast cancer growth.

bioRxiv : the preprint server for biology·2026
Same author

Diabetes-induced TREM2-endothelial cell signaling impairs ischemic vascular repair.

Science translational medicine·2026
Same author

Publisher Correction: Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation.

Nature neuroscience·2025
Same author

Author Correction: Human ocular fluid outflow on-chip reveals trabecular meshwork-mediated Schlemm's canal endothelial dysfunction in steroid-induced glaucoma.

Nature cardiovascular research·2025
Same author

Human ocular fluid outflow on-chip reveals trabecular meshwork-mediated Schlemm's canal endothelial dysfunction in steroid-induced glaucoma.

Nature cardiovascular research·2025
Same author

Astrocyte-driven vasoconstriction impairs glymphatic clearance in a human tauopathy-on-chip model.

APL bioengineering·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jun 18, 2026

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip
10:55

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Published on: October 21, 2013

14.3K

芯片上的淋巴体微生理系统:工程淋巴体结构和功能in vitro

Yansong Peng1, Esak Lee1

  • 1Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA. el767@cornell.edu.

Lab on a chip
|January 7, 2026
PubMed
概括

淋巴系统研究正在通过器官芯片技术取得进展. 这些微流体系统更好地模拟人类淋巴功能,以了解疾病和药物发现.

科学领域:

  • 生物工程是生物工程.
  • 细胞生物学 细胞生物学
  • 身体生理学 身体生理学

背景情况:

  • 淋巴系统在液体平衡,免疫监测和脂质吸收方面的作用至关重要,但往往被低估.
  • 传统的研究方法,如二维培养和动物模型,缺乏生理相关性和机械生物学复杂性,无法完全复制人类淋巴功能.
  • 吞吐量和生理学准确性的局限性阻碍了对淋巴系统动态的全面理解.

研究的目的:

  • 审查淋巴细胞器官芯片系统背后的基本原则和工程.
  • 突出这些微生理系统在模拟淋巴病和测试治疗药物的应用.
  • 探索整合IPSC和机器学习等先进技术用于淋巴研究的未来潜力.

主要方法:

  • 开发微流体器官芯片平台,结合3D架构,流体流动和生物机械刺激.
  • 在仿生微环境中共同培养人类淋巴内皮细胞和支持细胞.
  • 利用这些'芯片上的淋巴'结构,在各种条件下观察动态的细胞和流体行为.

主要成果:

  • 芯片上的淋巴系统成功地回顾了关键的淋巴功能,包括流体排水,结节重塑和细胞贩运.
  • 这些模型展示了与人类淋巴细胞疾病相关的生理和病理反应.
  • 与传统的研究方式相比,这些平台提供了增强的仿生学.

更多相关视频

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

3.8K
Author Spotlight: Magnetic Bead-Based Isolation of Murine Dermal Lymphatic Endothelial Cells
05:52

Author Spotlight: Magnetic Bead-Based Isolation of Murine Dermal Lymphatic Endothelial Cells

Published on: July 21, 2023

2.5K

相关实验视频

Last Updated: Jun 18, 2026

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip
10:55

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Published on: October 21, 2013

14.3K
A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

3.8K
Author Spotlight: Magnetic Bead-Based Isolation of Murine Dermal Lymphatic Endothelial Cells
05:52

Author Spotlight: Magnetic Bead-Based Isolation of Murine Dermal Lymphatic Endothelial Cells

Published on: July 21, 2023

2.5K

结论:

  • 微流体淋巴细胞微生理系统为促进淋巴系统研究提供了强大的工具.
  • 这些系统具有改善疾病建模和加速淋巴细胞疾病药物开发的巨大潜力.
  • 未来与干细胞技术和计算建模的整合有望进一步彻底改变淋巴细胞研究和治疗.