相关实验视频

Updated: Jan 13, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

呼吸见解:生物标志物作为慢性阻塞性肺病评估的工具 - - 一项系统性审查

Sonali Singh¹, Atul Kabra¹, Pradeep Goyal²

¹University Institute of Pharma Sciences, Chandigarh University, Ghauran, Punjab, India.

Indian journal of pharmacology

|January 7, 2026

概括

本综述探讨了慢性阻塞性肺病 (COPD) 的生物标志物,发现传统和新兴标志物的组合,以及临床数据,可以改善COPD诊断和个性化治疗策略.

科学领域:

肺部病理学肺部病理学
生物标志物发现发现
临床化学临床化学

背景情况:

慢性阻塞性肺病 (COPD) 在诊断和管理方面提出了重大的全球卫生挑战.
现有的COPD诊断和预后工具需要改进以获得更高的精度.
生物标志物对于理解COPD病理生理学和指导治疗至关重要.

研究的目的:

系统地审查目前关于COPD生物标志物的证据.
评估各种生物标志物的诊断,预后和治疗潜力.
为COPD护理中生物标志物的实用性提供最新的视角.

主要方法:

在PubMed和Scopus的系统文献搜索 (2019年1月至2025年4月).
包括成人COPD患者的观察性和随机研究.
由于异质性而导致数据的叙述综合;执行偏差风险评估.

主要成果:

传统的生物标志物 (例如,C-反应蛋白) 与COPD恶化风险和严重程度相关.
间白蛋白-6和-8在频繁的恶化症中升高;表面活性蛋白质有助于COPD的分化.
新兴的遗传和多组学标记在定义COPD表型和预测治疗反应方面表现有前途.

结论:

单个生物标志物提供了洞察力,但多标志物方法与临床数据相结合,可以提高COPD管理精度.
本次审查支持制定个性化和有效的COPD治疗策略.
为了改善临床应用,对综合生物标志物面板的进一步研究是有必要的.

关键词:

生物标志物生物标志物慢性阻塞性肺病慢性阻塞性肺病遗传学遗传学遗传学是一个系统性审查系统性审查

更多相关视频

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

相关概念视频

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

Chronic Obstructive Pulmonary Disease-V: Management

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

COPD: Management Using Bronchodilators and Corticosteroids

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...

Chronic Obstructive Pulmonary Disease-V: Nursing Management

Chronic Obstructive Pulmonary Disease-V: Nursing Management

Nursing management of Chronic Obstructive Pulmonary Disease (COPD) is crucial for providing thorough care and support to patients. Nurses play an integral role in this process through detailed assessment, careful planning, targeted interventions, and ongoing evaluation. Here's an overview of the critical steps in nursing management for COPD.
Assessment