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Updated: Jan 13, 2026

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Rsp5/NEDD4和ESCRT通过内分泌体清除机制调节TDP-43的毒性和营业额

Aaron Byrd1,2, Lucas J Marmorale1, Sophia Marcinowski1

  • 1Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA.

The Journal of cell biology
|January 7, 2026
PubMed
概括

研究人员确定了调节错位TDP-43蛋白质清除的关键基因,这是肌缩性侧面硬化症 (ALS) 的标志. 增强这种内分泌体清除途径可能为ALS提供新的治疗策略.

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