鱼类衍生生物材料在骨组织工程中:分子机制和支架创新用于增强再生
Haneen Fadhil Jasim1, Leqaa Majeed Aziz2, Zahraa Abbas Al-Khafaji3,4,5
1Medical Laboratory Techniques Department, College of Health and Medical Technology, University of Al-Maarif, Anbar, Iraq.
Naunyn-Schmiedeberg's archives of pharmacology
|January 7, 2026
概括
来自鱼类的原和酸为骨组织工程提供可持续的,生物相容的生物材料. 这些材料显示出与传统来源相比有前途的结构和生物优势,支持骨再生,降低免疫风险.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 组织工程是组织工程.
背景情况:
- 骨组织工程 (BTE) 依赖于模仿细胞外基质的生物材料来支持骨质生成和血管生成.
- I型原蛋白对BTE至关重要,但哺乳动物来源存在免疫性风险.
- 来自鱼类的原蛋白 (FC) 和酸 (HAp) 是可持续的,生物相容的替代品,免疫性降低.
研究的目的:
- 审查最近鱼类衍生生物材料对BTE的进展.
- 提供定量基准和机械洞察力,比较鱼类和哺乳动物衍生的材料.
- 评估鱼类生物材料在骨再生中的转化潜力.
主要方法:
- 对鱼类原体支架,生物陶,涂层和脱细胞化的研究进行系统分析.
- 机械性质的比较 (压力强度,弹性模量),多孔性和降解形状.
- 评估生物结果,包括骨质生成,血管生成和免疫调节.
主要成果:
- FC支架具有压力强度 (2-5 MPa),弹性模量 (50-150 MPa) 和多孔性 (60-90%) 适用于无骨骨.
- 退化速率 (4-12周) 与骨重塑时间表保持一致.
- 脱细胞化的鱼显示出增强的刚性和支持血管生成的层次结构;鱼骨生物陶促进骨质基因表达.
结论:
- 来自鱼类的生物材料比传统的支架提供了可量化的结构和生物优势.
- 基于FC的材料显示出改善的骨质导电性,可调节的降解性和较低的免疫性.
- 尽管在机械增强和临床验证方面存在挑战,但鱼类衍生生物材料在骨再生方面显示出显著的翻译潜力.
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