衰老的脏与代谢重新连接和表观遗传重编程有关
Pragney Deme1, Rhea Bhargava2, Heddwen L Brooks1
1Department of Physiology, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA, 70112, USA.
GeroScience
|January 7, 2026
概括
衰老的脏表现出改变的新陈代谢和增加的表代谢物,影响脏生理. 这些变化是性别特异的,揭示了衰老,新陈代谢和遗传在功能之间的复杂相互作用.
科学领域:
- 脏生理学 脏生理学
- 代谢学 代谢学 代谢学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 生物老龄化 生物老龄化
背景情况:
- 脏衰老涉及复杂的代谢和表观遗传变化.
- 已知衰老病的性别特异性差异是已知的,但不太了解.
- 代谢,表观遗传学和衰老的交集需要进一步研究.
研究的目的:
- 为了研究代谢途径的年龄和性别特异性变化.
- 检查衰老对脏内表观遗传修饰剂的代谢辅因子的影响.
- 阐明衰老期间代谢和表观遗传学之间的相互作用.
主要方法:
- 来自年轻和年长的性别匹配小鼠的均质被使用高性能液态染色学-三倍飞行时间 (HPLC-TripleTOF) 液态染色学-质谱学 (LC-MS) 分析.
- 量化了代谢物水平,包括表位代谢物和表观遗传辅因子代谢物.
- 进行了性别特定的代谢途径分析.
主要成果:
- 衰老的脏表现出葡萄糖分解增加,脂肪酸氧化减少,线粒体功能障碍,氧化应激和废物清除受损.
- 在老年小鼠中观察到甲基化和乙化中间代谢物 (表代谢物) 的水平升高.
- 关键的表观遗传辅因子代谢物 (乙-CoA,FAD,α-甲酸盐) 显示与年龄相关的变化.
- 与老年雄性相比,老年雌性小鼠表现出增强的氨基酸/酸代谢和减少的氨清除.
结论:
- 衰老会诱导脏中的显著代谢重编程,其特点是表皮代谢物质的增加.
- 脏中与年龄相关的代谢变化是性别特异的.
- 这些发现强调了代谢,表观遗传学和性别特异性的衰老过程之间的关键联系.
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