巴基斯坦的一项以焦虑为重点的行为干预计划中的维生素D水平和围产期焦虑
Semra Etyemez1,2, Kruti Mehta1, Jennifer Faiz1
1Department of Obstetrics & Gynecology, Weill Cornell Medical College, New York, NY, USA.
Archives of women's mental health
|January 7, 2026
概括
在巴基斯坦,孕产妇的维生素D缺乏严重. 虽然维生素D水平波动,但它们并没有因焦虑水平而有所不同,但免疫标记物影响了维生素D与焦虑的联系.
科学领域:
- 围产期健康 围产期健康
- 营养免疫学 营养免疫学
- 母亲心理健康 母亲心理健康
背景情况:
- 孕产妇维生素D缺乏是一个全球性问题,特别是在低收入和中等收入国家.
- 围产期焦虑会影响母亲和婴儿的福祉.
- 怀孕期间维生素D,焦虑和免疫功能之间的相互作用需要进一步调查.
研究的目的:
- 调查巴基斯坦妇女在整个产前期的维生素D水平.
- 检查维生素D状态,围产期焦虑和免疫标志物之间的关系.
- 探索免疫标记物如何调节维生素D与焦虑之间的关联.
主要方法:
- 对来自"快乐的母亲-健康的婴儿"试验的117名妇女的血25-氧维生素D,细胞因子和化学因子的分析.
- 血液样本是在四个围产期时间点 (10-38周怀孕和6周产后) 收集的.
- 对于焦虑群体和维生素D轨迹的混合效应模型进行K-means聚类;对免疫标记物效应进行适度分析.
主要成果:
- 严重的维生素D缺乏 (<5ng/ml) 在所有时间点都普遍存在,从怀孕早期到晚期显著下降.
- 在焦虑组之间没有发现维生素D轨迹的显著差异.
- 较高的先天性免疫活性与在T1时更高的维生素D相关. 介质素-6 (IL-6) 和CXCL-8在T2中调节了维生素D与焦虑的关系,较高的维生素D与女性高IL-6和CXCL-8的焦虑相关.
结论:
- 在巴基斯坦,孕产妇的维生素D缺乏是严重的问题.
- 像IL-6和CXCL-8这样的免疫标志物可能会影响维生素D和围产期焦虑之间的关系.
- 需要进一步的研究,以了解低收入和中等收入国家母亲的维生素D缺乏和免疫功能.
相关概念视频
01:19Autism Spectrum Disorder
956
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
956
01:28Social Anxiety Disorder
432
Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
432
01:30Generalized Anxiety Disorder
621
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
621
01:18Anxiety: Overview
887
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
887