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Updated: May 3, 2026

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在长期COVID中状变化及其与IL-6的关联

Yuan Cao^1,2,3,4, Paulo Lizano^5,6, Alejandra P Garza⁷

¹Department of Psychiatry and Psychotherapy, Jena University Hospital, 07743, Jena, Germany.

European archives of psychiatry and clinical neuroscience

|January 7, 2026

概括

长期的COVID患者表现出较小的胆脉 (ChP) 体积,与增加的IL-6 (IL-6) 和神经炎症有关. 这表明长期COVID中持续存在的血液-脑脊液屏障问题,影响大脑健康.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

感染SARS-CoV-2可以通过ACE-2受体扰乱胆脉 (ChP) 表皮,可能导致血液-脑脊液 (CSF) 屏障泄漏.
这种干扰可能会让介质素-6 (IL-6) 和病原体进入大脑,导致白质 (WM) 损伤和长期COVID中观察到的神经症状.

研究的目的:

为了调查状 (ChP) 在长期COVID中的作用.
在长期COVID患者中检查CHP体积,WM完整性,IL-6水平,临床症状和ACE抑制剂/血管新生素II受体抑制剂 (ACEIs/ARBs) 之间的关系.

主要方法:

在52名长期COVID患者,21名COVID-19幸存者和26名健康对照 (HC) 中比较了CHP体积和WM完整性.
评估抑郁症 (MADRS) 和认知功能 (MoCA) 评分,并测量IL-6水平.
利用部分相关性来探索CHP体积,IL-6,分数异构组织 (FAt) 和症状之间的关系. 此外,ChP的数量也被追踪了一年.

主要成果:

与其他组相比,长期COVID患者的MoCA得分明显较低,MADRS得分较高,ChP体积较小.
在长期COVID患者中,较大的ChP体积与较高的IL-6水平相关.
与基线相比,COVID-19幸存者在随访时显示ChP体积增加,与长期COVID患者不同.

结论:

长期COVID中较小的CHP体积可能表明持久的,低度的血液-中枢神经液屏障功能障碍和上皮压力.
长期COVID患者的IL-6水平升高可能会影响ChP的透性,这表明正在进行的神经炎症.
状交叉体完整性和IL-6水平是长期COVID中神经系统并发症的潜在生物标志物.

关键词:

冠状动脉 (choroid plexus) 是一个动脉的组成部分.免费的水免费的水介乐金-6 介乐金-6 是一种长时间的COVID.

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