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由生物信息学驱动的共同生物标志物的发现,这些生物标志物将抑郁症与认知障碍联系起来

Weizhi Chen¹, Bin Li¹

¹Department of Neurology, Washington Scientific Institute, Fairfax, USA.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

|January 7, 2026

概括

重度抑郁症 (MDD) 和轻度认知障碍 (MCI) 分享301个差异表达的基因,突出神经炎症和氧化应激途径. 像PARP1和CDC42这样的关键基因可能提供诊断和治疗目标.

科学领域:

神经科学是一个神经科学.
遗传学是一个遗传学.
生物信息学是一种生物信息学.

背景情况:

重度抑郁症 (MDD) 经常与轻度认知障碍 (MCI) 一起发生.
这种并发症的潜在分子机制尚不清楚.
识别共享的分子通路对于理解和治疗这些疾病至关重要.

研究的目的:

为了确定MDD和MCI之间共享的差异表达基因 (DEGs).
揭示共同的生物学途径,涉及到共同疾病.
发现早期诊断和新的治疗点的潜在分子生物标志物.

主要方法:

来自MDD (GSE58430) 和MCI (GSE140831) 患者的转录组数据集的分析.
使用生物信息学识别差异表达基因 (DEGs).
通过基因本体学 (GO) 和基因和基因组的京都百科全书 (KEGG) 进行功能丰富分析.
构建蛋白与蛋白相互作用 (PPI) 网络以识别核心基因.

主要成果:

301个DEG在MDD和MCI队列中都是常见的.
丰富分析表明神经炎症,氧化应激,突触功能障碍和亡的参与.
通过PPI网络分析确定了9个枢纽基因,包括HSP90AB1,CDC42,NFKB1和PARP1.

结论:

共享的分子生物标志物和途径将MDD和MCI联系起来,提供了对它们的共患病态的见解.
已识别的枢纽基因,特别是PARP1和CDC42,代表了有前途的目标.
这些发现可以促进精神病和神经退行性疾病的早期诊断和基于机制的治疗.

关键词:

生物信息学是一种生物信息学.生物标志物生物标志物基因表达的基因表达方式大型抑郁症主要是抑郁症.轻度的认知障碍轻度的认知障碍

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