陶,心血管健康和心血管风险的种族差异:初步分析
Mathias Lalika1, Vlad C Vasile1,2, Matthew P Johnson3
1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, USA.
概括
胺等离子体评分与非裔美国人的心血管健康或疾病风险没有关联. 尽管心脏代谢状况较差,但非洲裔美国人的胺含量低于白人成年人,这表明在这个人群中风险预测的效用有限.
科学领域:
- 心血管疾病研究研究
- 生物标记分析 生物标记分析
- 种族健康差异的差异
背景情况:
- 血陶是已确定的心血管风险生物标志物.
- 关于非裔美国人的胺水平和心血管健康 (CVH) 的研究是有限的.
- 了解陶中的种族差异对于准确的风险评估至关重要.
研究的目的:
- 评估陶胺评分与CVH和动脉样硬化心血管疾病 (ASCVD) 风险在非裔美国成年人之间的关联.
- 为了比较非裔美国人和白人成年人的胺分数.
- 为了调查在心血管风险分层中胺功效的潜在基于种族的差异.
主要方法:
- 美国两项涉及非裔美国人和白人成年人的研究的二次分析.
- 收集的数据包括人口统计,生活方式因素和血陶胺水平.
- 使用ACC/AHA聚合方程计算ASCVD风险;使用AHA生命的基本8 (LE8) 评分评估CVH.
主要成果:
- 非洲裔美国人 (n=58) 与白人 (n=1103) 相比,肥胖,高血压,糖尿病和高脂血症的发病率更高,但ASCVD风险相似.
- 在非裔美国人中,胺分数和LE8或ASCVD风险之间没有发现显著的关联.
- 与白人成年人相比,非洲裔美国人表现出较低的特定胺物种水平 (18:0和24:1).
结论:
- 在被研究的非裔美国人中,胺分数与心血管炎症或ASCVD风险无关.
- 非洲裔美国人呈现出较低的胺水平,尽管他们的心脏代谢状况不那么有利.
- 目前的胺评分可能不是非洲裔美国人心血管风险的可靠指标.
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