治疗阿片类药物戒断和自主调节:一项随机临床试验
Suddala Goutham1, Hemant Bhargav1, Bharath Holla1
1Department of Integrative Medicine, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
显著加快了阿片类药物戒断的恢复速度,并改善了自主调节,焦虑,睡眠和疼痛. 这种辅助疗法提供了一种神经生物学知情的方法,以提高患者的治疗结果.
科学领域:
- 综合医学是一个整体的医学.
- 神经科学是一个神经科学.
- 药物中毒药物 药物中毒药物
背景情况:
- 阿片类药物戒断的特点是交感性过度活跃和降低的副交感性音调,通常不充分地通过标准治疗来解决,导致复发.
- 在阿片类药物戒断期间,标准的药理干预可能无法完全恢复自主平衡.
研究的目的:
- 研究作为一种辅助疗法,以加速阿片类药物戒断恢复.
- 评估对阿片类药物戒断患者心率变化,焦虑,睡眠和疼痛的影响.
主要方法:
- 一个双臂随机临床试验,涉及59名患有轻度至中度阿片类药物戒断症状的成年人.
- 参与者接受了标准的布普伦诺芬治疗,干预组也在14天内进行了10次监督课程.
- 同一主要结局包括戒断稳定时间和心率变化;二级结局包括焦虑,睡眠延迟和疼痛.
主要成果:
- 与对照组相比,组表现出明显更快的戒断稳定 (中位数为5天而不是9天) (HR,4.40;P <.001).
- 干预导致心率变化 (低频率,高频率和LF/HF比率;P < .001) 的优异改善,并显著减少了焦虑 (P < .001).
- 副交感活动的改善介于治疗效果的23%,在睡眠延迟和疼痛方面观察到显著的好处.
结论:
- 作为辅助疗法的显著加速了阿片类药物戒断的恢复.
- 可以改善自主调节,减少焦虑,减轻阿片类药物使用障碍患者的疼痛和睡眠障碍.
- 研究结果支持将纳入阿片类药物戒断方案,作为针对核心监管过程的补充干预措施.
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