与健康相关的生活质量和心脏骤停后的长期存活率
Emelie Dillenbeck1, Per Nordberg1,2,3, Akil Awad1
1Department of Clinical Science and Education, Center for Resuscitation Science, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
JAMA network open
|January 7, 2026
概括
心脏骤停后与健康相关的生活质量 (HRQOL) 差,与长期存活率的降低有关. 这一发现突显了HRQOL的价值.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 生活质量研究 研究 生命质量研究
背景情况:
- 与健康相关的生活质量 (HRQOL) 随访提供了患者对心脏骤停结果的观点.
- HRQOL与心脏骤停后的长期存活率之间的关联在很大程度上是未知的.
研究的目的:
- 确定心脏骤停后3-6个月评估的HRQOL是否与长期存活相关.
主要方法:
- 在瑞典进行了一项为期7年的队列研究,将5个国家注册表联系起来,包括住院 (IHCA) 和外院 (OHCA) 心脏骤停的幸存者.
- 参与者 (n=3108) 在心脏骤停后至少存活了90天,并填写了EQ-5D-5L问卷.
- 分析使用了EuroQoL 5维5级 (EQ-5D-5L) 级别总和得分 (LSS) 和视觉模拟尺度 (EQ VAS) 来评估HRQOL.
主要成果:
- 在IHCA幸存者中,较高的LSS得分 (表明较差的HRQOL) 与死亡风险增加有关 (AHR,2.50对于LSS 11-25与LSS 5).
- 在OHCA幸存者中,没有发现LSS类别与长期存活之间的显著关联.
- 连续线建模表明,较差的HRQOL (较高的LSS,较低的EQ VAS) 与IHCA和OHCA组的死亡风险增加相关,尽管OHCA的不确定性更大.
结论:
- 心脏骤停后3-6个月的较差HRQOL与IHCA和OHCA幸存者的长期生存率降低有关.
- 与OHCA组相比,在IHCA组中,HRQOL和生存率之间的关联更为明显和确定.
- 心脏骤停后的HRQOL评估可能是指导患者随访护理和预测长期结果的宝贵工具.
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