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Updated: Jan 13, 2026

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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缺陷的DNA损伤反应是ESR1突变乳腺癌中可向的治疗脆弱性

Sarah K Herzog1, Jessica H Stevens2, Guowei Gu1

  • 1Baylor College of Medicine Houston, TX United States.

Cancer research
|January 7, 2026
PubMed
概括

雌激素受体1 (ESR1) 突变在转移性乳腺癌中驱动对内分泌治疗的耐药性. 用PARP抑制剂向DNA损伤反应显示出治疗这种耐药癌症亚群的前景.

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