测量和计算二碳酸盐之间的仪器特定变异的评估
Nga Yeung Tang1, Carmen Gherasim2, Lee Schroeder2
1Department of Pathology, University of Illinois Chicago, Chicago, IL, United States.
The journal of applied laboratory medicine
|January 7, 2026
概括
测量二碳酸盐 (mHCO3-) 和计算二碳酸盐 (cHCO3-) 之间的差异可能会导致诊断混. 这项研究发现Radiometer和一些化学分析仪之间有很好的协议,但注意到Abbott Architect的偏见.
科学领域:
- 临床化学 临床化学
- 酸平衡是指酸平衡的情况.
- 诊断的准确性 诊断的准确性
背景情况:
- 二碳酸盐度对于评估酸性疾病至关重要.
- 测量 (mHCO3-) 和计算 (cHCO3-) 碳酸盐之间的差异可能导致临床混和误诊.
- 准确的二碳酸盐测量对于患者管理至关重要.
研究的目的:
- 评估放射仪血液气体分析仪计算的二碳酸盐 (cHCO3-) 与三种不同的化学仪器测量的二碳酸盐 (mHCO3-) 之间的一致性.
- 在不同分析平台上识别二碳酸盐测量中的潜在偏差.
- 提高酸性疾病评估的可靠性.
主要方法:
- 涉及三个不同的化学分析仪制造商的多机构研究.
- 在20分钟的窗口内收集了包括血mHCO3-和血气cHCO3- (动脉和静脉) 在内的非身份患者数据.
- 使用德明回归和布兰德-阿尔特曼分析来确定相关性和偏差.
主要成果:
- 在所有平台上观察到cHCO3-和mHCO3-之间的良好相关性.
- 布兰德-阿尔特曼分析显示,Radiometer和Abbott Architect (-2.63 mmol/L) 之间的偏差最大.
- 与Radiometer相比,西门子Advia (0.49 mmol/L) 和贝克曼AU680 (-0.45 mmol/L) 的偏差是最小的.
结论:
- 这项研究是第一个将Radiometer cHCO3-与多个化学分析仪的mHCO3-进行比较的研究.
- 放射仪血气分析仪,西门子Advia和贝克曼AU680显示出很好的协议.
- 与其他方法相比,Abbott Architect可能会在二碳酸盐测量中表现出负偏差,这需要临床关注.
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