在检测结直肠癌复发时,eNose技术的诊断性能:前性评估
Ivonne J H Schoenaker1,2, Henderik L van Westreenen3, Evelyn J Finnema2
1Oncology Center Isala, Zwolle, the Netherlands.
PloS one
|January 7, 2026
概括
电子鼻子 (eNose) 技术在手术后检测复发性结肠直肠癌 (CRC) 的准确性有限. 需要进一步的研究,以提高其诊断性能和临床使用的可重复性.
科学领域:
- 在瘤学瘤学.
- 医学诊断 医学诊断 医学诊断
- 生物技术是生物技术.
背景情况:
- 结肠直肠癌 (CRC) 复发影响了治疗后15%的患者.
- 早期发现无症状复发对于治疗选择至关重要.
- 目前的后续策略缺乏最佳的灵敏度和特异性.
研究的目的:
- 评估eNose技术用于检测复发性CRC的诊断性能.
- 评估eNose在手术后区分复发性和非复发性CRC患者的能力.
主要方法:
- 涉及406名接受治疗性CRC切除 (2018-2023) 的患者的前性研究.
- 利用eNose技术分析挥发性有机化合物 (VOC) 模式以检测复发.
- 开发并评估了一种用于诊断性能的机器学习模型,使用准确度,灵敏度和AUC等指标.
主要成果:
- 在训练组中,eNose模型在训练组中实现了0.90的AUC,但显示精度低 (0.56).
- 在测试组中,性能显著下降,准确度为0.51,灵敏度为0.52,AUC为0.51.
- 在eNose技术证明了不足的诊断准确性,用于反复的CRC检测.
结论:
- 目前eNose技术还不够准确,无法检测复发性CRC治疗后切除.
- 需要进行更大规模的多中心研究来验证研究结果并解决可重现性问题.
- 对于CRC复发检测eNose的临床实施尚未可行.
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