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Updated: Jan 13, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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构造工程,BSA结合和计算分析含有1,2,4-三醇的基于异尼酸盐的酶抑制剂

Naeem A Virk1, Aziz-Ur-Rehman1, Javed Iqbal2

  • 1Department of Chemistry, Government College University, Lahore, Pakistan.

PloS one
|January 7, 2026
PubMed
概括

这项研究使用微波辅助方法合成了基于piperidine的新型1,2,4-triazole类似物,具有高产量. 几种化合物对乙胆酶 (AChE),丁胆酶 (BChE) 和15-氧基酶 (15-LOX) 酶表现出显著的抑制活性.

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