邻居环境空气污染和移植后的结果在年长的脏移植接受者中
Gayathri Menon1, Malika Wilson1, Yiting Li1
1Department of Surgery, New York University Grossman School of Medicine, New York, New York, USA.
Journal of the American Geriatrics Society
|January 7, 2026
概括
居住在空气污染较高的地区增加了老年移植接受者的死亡率和移植失败风险. 暴露于PM2.5和NO2等污染物也会增加这一弱势群体中风风险.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學.
- 流行病学 流行病学
背景情况:
- 环境空气污染物的增加与老年人的不良健康结果有关.
- 老年移植 (KT) 接受者可能更容易受到免疫抑制和并发症的影响.
- 这项研究调查了空气污染物度对老年接受者的后KT结果的影响.
研究的目的:
- 量化环境空气污染物度与KT接受者中老年人死亡风险之间的关联.
- 在这个人群中评估空气污染物暴露与死亡审查移植缺陷 (DCGF) 之间的关系.
- 检查空气污染对KT后痴呆和中风风险的影响.
主要方法:
- 利用年龄较大 (≥55岁) 黑白KT接受者的国家注册 (2003-2019) 与医疗保险索赔相关.
- 获得的年度污染物度 (PM2.5,PM10,NO2,SO2) 通过KT的邮政编码和年份进行匹配.
- 员工共享脆弱性和竞争风险模型,以估计死亡率,DCGF,痴呆和中风的危险和次危险比率.
主要成果:
- 增加PM2.5,PM10,NO2和SO2度与较高的死亡风险显著相关.
- 更高的污染物度也与死亡审查的移植失败的风险增加有关.
- 虽然痴呆风险与污染物没有显著相关,但PM2.5和NO2暴露显示中风风险略有增加.
结论:
- 居住在空气污染较高的社区会对KT接受者中老年患者和移植者的存活率产生不利影响.
- 暴露于空气污染与KT接受者中老年人中中风风险增加有关.
- 建议针对受污染地区的老年人进行查和干预,以改善健康结果.
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