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替代除草剂l-glufosinate诱导的发育效果与 Racemic-Glufosinate 的效果相似

Bixia Peng^1,2, Ziyuan Qi^1,2, Daniel Schlenk³

¹State Key Laboratory of Soil Pollution Control and Safety, Zhejiang University, Hangzhou 310058, China.

Environmental science & technology

|January 7, 2026

概括

除草剂反体l-glufosinate-ammonium (l-GLA) 和raceme-glufosinate-ammonium (raceme-GLA) 通过损害胎盘代谢导致胎儿生长受限. 这挑战了l-GLA作为一种被禁止的种族GLA的替代品的安全性.

科学领域:

生殖毒理学生殖毒理学
发育生物学发展生物学
环境健康环境健康

背景情况:

葡萄酸 (GLA) 由于对发育有毒性,在欧盟被禁止使用.
该l-enantiomer (l-GLA) 作为一种更安全的替代品销售,但缺乏毒性评估.
在这项研究中,使用了与人类相关的GLA反体的血清度.

研究的目的:

在怀孕小鼠中研究l-GLA和racemic-GLA的生殖和发育毒性.
评估GLA反体对胎盘功能和胎儿发育的影响.
探索GLA诱导的发育毒性的潜在机制.

主要方法:

怀孕的小鼠被暴露在l-GLA和racemic-GLA的13和130微克/公斤/天.
评估胎儿生长,胎盘体重,胎盘结构和亡.
分析了与胎盘代谢相关的基因表达 (和) 和补充的人类胎盘细胞.

主要成果:

产前对l-GLA和racemic-GLA的暴露导致胎儿生长受限和胎盘体重降低.
通过改变关键代谢酶 (Arg1,Aoc1,Maoa,Hoga1) 的基因表达,GLA 抗体损害了胎盘代谢,导致减少了特素和酸盐.
补充普素或酸盐在体外挽救受损的热囊细胞迁移和入侵.

结论:

环境相关的l-GLA和racemic-GLA剂量通过代谢重编程诱导胎盘功能障碍和胎儿生长限制.
这些发现挑战了l-GLA作为racemic-GLA的替代品的安全性.
GLA 反体对生殖和发育健康构成风险.

关键词:

这是一种性除草剂 (chiral herbicide).胎儿生长限制限制胎儿生长葡萄酸-氨基的使用 l-葡萄酸盐-氨基代谢重编程是指代谢重编程.胎盘毒性胎盘毒性布特雷斯基因 (Putrescine) 是一种有毒的药物.皮鲁酸是一种酸盐.

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Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...