维生素B12水平与结肠癌存活率之间的关联:全球网络研究
Bruce Chang-Gu1, George Golovko2, Anthony P D'Andrea2
1The University of Texas Medical Branch at Galveston Galveston United States.
Cancer research communications
|January 7, 2026
概括
维生素B12水平升高与结肠癌患者的病情恶化有关,包括转移率增加和生存率降低. 这突出了维生素B12作为结肠癌进展的潜在生物标志物.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 遗传学 是一个遗传学.
背景情况:
- 新兴研究表明,维生素B12水平升高与恶性瘤发病率更高之间存在相关性.
- 了解维生素B12在结肠癌进展中的作用对于识别新的生物标志物和治疗点至关重要.
研究的目的:
- 调查维生素B12水平与结肠癌患者的不良结果之间的关联,特别关注转移和死亡率.
- 探索维生素B12水平,瘤特征和患者存活率之间的关系.
- 分析与结肠癌中维生素B12代谢相关的基因表达模式.
主要方法:
- 一个多机构数据库 (TriNetX) 的回顾性分析,涉及37,106名结肠癌患者与维生素B12测量.
- 患者被分为低 (<300 pg/mL),正常 (300-1000 pg/mL) 和高 (>1000 pg/mL) 维生素B12组.
- 统计分析包括日志等级测试,考克斯比例危险模型和风险比率,以比较生存率,转移率和癌症基因组图谱 (TCGA) 和基因型-组织表达 (GTEx) 项目中的基因表达.
主要成果:
- 与正常 (129.8个月) 和低 (137.3个月) 水平相比,较高的维生素B12水平与平均整体存活时间 (59.4个月) 的显著下降有关.
- 维生素B12含量较高的患者表现出更高的转移性参与率,在诊断时的晚期瘤阶段,以及肝脏,肺部和腹转移的1年发病率增加.
- 基因表达分析显示,结肠癌组织中维生素B12依赖的甲氨酸合成酶 (MTR) 的水平较高,与生存率较差相关.
结论:
- 维生素B12水平升高是结肠癌不良结果的重要指标,包括转移的增加和生存率的降低.
- 这些发现表明,维生素B12可能成为预测结肠癌进展和患者预后的有价值的临床生物标志物.
- 对MTR在结肠癌发病过程中的作用的进一步研究可能会揭示新的治疗策略.
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