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暴露于di-n-pentyl甲酸盐会改变小鼠的肠道结构和肠道微生物群的组成和特征

Yanyouhong Liu¹, Liting Zhong¹, Chaoming Zhou¹

¹Department of Oncology, Ganzhou Hospital-Nanfang Hospital, Southern Medical University, Ganzhou, Jiangxi, China; Department of Oncology, Ganzhou People's Hospital, Ganzhou, Jiangxi, China.

Ecotoxicology and environmental safety

|January 7, 2026

概括

丁甲 (DnPP) 通过改变肠道细菌和减少有益的微生物,导致小鼠的肠道损伤和炎症. 这种塑化剂对肠道健康,新陈代谢构成风险,并增加抗生素耐药性.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
微生物学微生物学

背景情况:

丁甲 (DnPP) 是一种塑化剂,其结构类似于已知肠道毒素DEHP.
已知DnPP的环境持久性和人类暴露风险,但其胃肠道毒性研究不足.
这项研究调查了DnPP通过肠道微生物群失调来破坏肠道平衡的潜力.

研究的目的:

在小鼠模型中研究Di-n-pentyl甲酸 (DnPP) 的胃肠道毒性.
确定DnPP对肠道结构,炎症以及肠道微生物群的组成和功能的影响.
阐明DnPP可能破坏肠道平衡的机制.

主要方法:

小鼠被口服DnPP (1-100毫克/公斤/天) 持续21天.
肠道组织使用组织形态测量分析.
肠道微生物群的组成和功能通过元基因组测序和功能注释来评估.

主要成果:

DnPP诱导的剂量依赖性小毛病退化和结肠缩短.
炎症性细胞因子 (IL-6,TNF-α) 的上调,而紧结蛋白 (ZO-1,ocludin) 的下调.
观察到组织特异性肠道失调,细菌种群发生变化,代谢途径减少,抗生素耐药性基因增加.

结论:

DnPP破坏肠道结构,诱导炎症,并改变小鼠的肠道微生物群.
这些发现表明潜在的健康风险,包括由于肠道功能受损和抗生素耐药性增加而导致的代谢和传染病.
这项研究提供了关键的机理洞察力,了解甲酸对健康的危害.

关键词:

细菌杆菌的发生.丁--乙烯甲酸二甲酸二烯甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸胃肠道毒性胃肠道毒性我们的肠道微生物群.甲酸 Ester 是一种甲酸.

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