聚钢和聚乙烯微塑料暴露会诱导眼睛表面炎症,因而导致线粒体损伤和脂质代谢中断
Binyu Wen1, Bosheng Ma1, Hui Tao1
1Department of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, PR China.
Journal of hazardous materials
|January 7, 2026
概括
像聚钢 (PS) 和聚乙烯 (PVC) 这样的微塑料通过破坏线粒体和扰乱角膜细胞中的脂质代谢,引起眼睛炎症. 针对线粒体和脂质通路的治疗可以减少这种微塑料诱导的眼睛毒性.
科学领域:
- 眼科医生 眼科 眼科
- 环境毒理学环境毒理学
- 细胞生物学 细胞生物学
背景情况:
- 微塑料 (MPs),包括聚钢 (PS) 和聚乙烯 (PVC),是广泛存在的污染物.
- 国会议员与眼睛表面损伤有关,但分子机制尚不清楚.
研究的目的:
- 为了研究PS/PVC诱导的眼表面炎症的分子途径.
- 为了确定微塑料相关的眼损伤的潜在治疗点.
主要方法:
- 使用暴露于PS/PVC颗粒的人类角膜上皮细胞 (HCE-T) 的体外研究.
- 在体内研究涉及眼睛表面暴露的小鼠模型.
- 综合转录组和代谢组分析.
- 评估线粒体功能和脂质代谢.
主要成果:
- PS/PVC颗粒被HCE-T细胞内化,导致细胞毒性和炎症.
- 在小鼠的眼部暴露导致了类似干眼的症状.
- MPs诱导了线粒体损伤 (mPTP开放,mtDNA泄漏) 和破坏了脂质代谢 (LIPG,GRB14失调).
- 由于能量压力,PS/PVC暴露增加了脂质滴-线粒体结合.
结论:
- 线粒体功能障碍和脂质代谢干扰是PS/PVC诱导的眼睛炎症的关键机制.
- 用抗氧化剂 (SkQ1) 或皮菌素受体激活剂向线粒体可以减少角膜炎症.
- 这些发现提供了对微塑料眼部毒性的见解,并提出了治疗策略.
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