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克服功能性蛋白质的口服输送障碍:当前状态和先进的输送技术

Zhang Jianghao¹, Salumu Masuwa Shadrack¹, Wang Mingcheng²

¹School of Life Science, Shaoxing University, Shaoxing, Zhejiang, China; Department of Food Quality and Safety, National R&D Center for Chinese Herbal Medicine Processing, College of Engineering, China Pharmaceutical University, Nanjing, Jiangsu, China.

|January 7, 2026

概括

功能性食品蛋白和面临着口服输送的挑战. 本综述探讨了先进的传递系统和人工智能,以提高它们的稳定性和生物可用性,以提高健康益处.

科学领域:

营养科学营养科学
生物技术是生物技术.
制药科学制药科学

背景情况:

功能性食品中的蛋白质和具有健康益处,但由于溶解性低,降解和吸收不良,难以通过口服输送.
这些局限性大大阻碍了它们的功能性能和治疗疗效,当口服时.

研究的目的:

审查影响功能蛋白和的口服输送的主要障碍.
评估关键的输送策略及其对稳定性和生物可用性的影响.
讨论智能交付系统和人工智能在推进这些技术中的作用.

主要方法:

文献综述总结了口服蛋白质/交付方面的挑战.
各种输送系统的概述:基于脂质的,聚合物的,粘膜的和物理化学的.
探索智能交付系统和AI/ML在配方开发中的应用.

主要成果:

确定了包括低溶解度,酶降解和胃肠道不稳定性在内的关键障碍.
突出了各种交付策略,以提高稳定性和生物可用性.
强调了智能系统和AI/ML在优化航母设计和加速开发方面的潜力.

结论:

先进的输送系统对于克服功能性蛋白质和的口服生物可用性问题至关重要.
智能交付系统和AI/ML为下一代配方提供了有前途的途径.
需要进一步的研究来弥合知识差距,并优化这些系统以改善健康结果.

关键词:

人工智能的人工智能是人工智能.功能性蛋白质是一种功能性蛋白质.纳米颗粒纳米颗粒这是口头传递.智能交付系统是智能交付系统.有针对性的交付目标.

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