在ADHD中改变了肠道微生物组功能:更多的Prevotella,更少的维生素B12生物合成,以及通过协生治疗的有益调节
Miranda Stiernborg1, Liu L Yang2, Elin Skott3
1Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.
Brain, behavior, and immunity
|January 7, 2026
概括
这项研究揭示了ADHD成年人肠道微生物组的明显差异. 在ADHD患者中,Synbiotic 2000调节了肠道微生物组,并增加了短链脂肪酸 (SCFA).
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物组在注意力缺陷多动症 (ADHD) 中的作用基本上是未知的.
- 精神刺激药物是常见的多动症治疗方法,但它们对肠道微生物组的影响尚未被探索.
- Synbiotic 2000是一种益生菌和益生菌,对ADHD症状减轻有前途.
研究的目的:
- 与对照人群相比,对ADHD患者的便细菌微生物组进行表征.
- 研究Synbiotic 2000对ADHD患者肠道微生物群的影响.
- 探索精神兴奋剂,肠道微生物组合和宿主因素之间的关联.
主要方法:
- 从147名ADHD参与者和106名完成者的便样本进行了浅射枪测序.
- 机器学习分析微生物群多样性和差异丰度.
- 血短链脂肪酸 (SCFA) 和血清维生素B12的测量.
主要成果:
- 成年ADHD患者与对照人群相比,表现出四种细菌物种的丰度变化.
- 接受精神兴奋剂的儿童增加了Prevotella和减少了维生素B12合成模块 (M00122).
- 合成生物2000改变了微生物群的多样性,并增加了血SCFA水平 (酸和酸).
结论:
- 不同的肠道细菌物种与成年人患ADHD有关.
- 患有ADHD的儿童使用精神兴奋剂与特定的微生物组和代谢变化有关.
- 在ADHD治疗中,Synbiotic 2000显示了调节肠道微生物组和SCFA水平的潜力.
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