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Updated: Jul 25, 2026

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
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维生素A-精子结合脂质纳米颗粒用于有效的核酸输送到眼球和肝细胞细胞中

Jinliang Ye1, Xinli Fan2, Yizhi Man1

  • 1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, No.38 Xueyuan Rd., Beijing 100191, China.

International journal of pharmaceutics
|January 7, 2026
PubMed
概括

研究人员使用维生素A和精氨酸开发了一种新的脂质纳米粒子 (LNP) 输送系统. 这种新的试剂,VA-6C-Sper/DOPE,与商业选择相比,显示出更高的核酸输送效率.

关键词:
脂质纳米颗粒的使用方法核酸输送核酸的交付方式精子结合物是精子的结合物.维生素A 维生素A是一种维生素.

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...