3D打印的粘膜粘合性胃贴片提供长效的纳尔特雷克松输送
Srivarsha Reddy Bollareddy1, Neeharika Vatsavai1, Venkata Vamsi Krishna Venuganti1
1Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Hyderabad 500078 Telangana, India.
International journal of pharmaceutics
|January 7, 2026
概括
这项研究开发了一种3D打印的粘膜粘合性胃贴片,用于长效纳特雷克松 (NTX) 输送,该贴片显示了持续35天的血度,并减少了大鼠的炎症标志物.
科学领域:
- 药物输送系统 药物输送系统
- 生物材料科学 生物材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 片类药物和酒精依赖障碍需要有效的长期治疗策略.
- 目前的治疗方法往往涉及频繁的剂量,影响患者的坚持.
- 需要新的药物输送系统来改善治疗结果和遵从性.
研究的目的:
- 制造和描述3D打印的粘膜粘合性胃贴片,用于持续释放纳尔特雷 (NTX).
- 评估开发的带NTX补丁的体外药物释放,体外透和体内药理动力学.
- 评估贴片在管理与物质依赖相关的炎症标志物的潜力.
主要方法:
- 使用3D打印制造粘膜贴片,使用聚烯酸,聚乳酸,碳素甲基纤维素,Eudragit RS 100,Carbopol 934P和聚乙烯糖醇 400.
- 用奇托 - 碳基酸合物覆盖贴片,以增强粘膜粘合力,并使用聚烯酸/聚二甲基西洛酸支持层.
- 描述包括拉伸强度,表面形态,膨胀指数和接触角度.
- 在试验室释放,ex vivo胃粘膜透,并在老鼠模型中进行了体内药理动力学研究.
主要成果:
- 3D打印的贴片在98天内显示出100%的纳尔特雷释放.
- 活体外研究表明,与溶液相比,贴片的NTX透率显著降低 (177 ± 17 vs 872 ± 68μg/cm2).
- 在体内,单次NTX贴片给药维持了血NTX水平35天,相当于每天给药溶液,但炎症标志物没有显著增加.
结论:
- 一个3D打印的粘膜粘合性胃补丁是一种可行的技术,用于长期作用的纳尔特雷输送.
- 该贴片有效地维持药物释放和血度,可能改善阿片类药物和酒精依赖的治疗坚持.
- 这种方法为传统的剂量方案提供了一个有希望的替代方案,对控制炎症反应有影响.
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