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在慢性乙肝B型肝炎患者接受干扰素α疗法期间,抗干扰素α抗体和HBsAg血清清除

Chuan Jiang¹, Da Cheng², Wenting Peng¹

¹Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

|January 7, 2026

概括

较低的基线HBsAg和较年轻的年龄预测了Peg-IFNα治疗的慢性乙型肝炎 (CHB) 患者的HBsAg清除. 抗干扰素αIgM的早期升高表明治疗反应不佳.

科学领域:

肝病学肝病学是一种肝病学.
免疫学免疫学免疫学
病毒学病毒学

背景情况:

慢性乙型肝炎 (CHB) 是一个重要的全球健康问题.
干扰素-α (Peg-IFNα) 是治疗心脏病的一种选择.
预测治疗反应和了解免疫反应对于优化CHB管理至关重要.

研究的目的:

在接受Peg-IFNα的CHB患者中确定HBsAg血清清除的预测因子.
评估抗干扰素α (抗IFNα) 抗体的产生与治疗结果之间的关联.

主要方法:

根据Peg-IFNα反应对77名CHB患者进行了分类 (12周反应者,24周反应者,24周无反应者).
利用多变量逻辑回归来确定HBsAg清除的独立预测因子.
分析了抗IFNα抗体变化与治疗反应之间的关系.

主要成果:

较低的基线HBsAg预测了12周的HBsAg清除.
较低的基线HBsAg和较年轻的年龄预测到24周的HBsAg清除.
在不响应者中,抗IFNα IgG和IgM增加,IgM呈现最明显的增加;抗体标位在响应者中保持稳定.

结论:

较低的基线HBsAg和较年轻的年龄与Peg-IFNα治疗24周内更高的HBsAg清除率有关.
抗IFNα IgM的早期和显著增加可能作为CHB中Peg-IFNα治疗反应不佳的早期预警标志物.

关键词:

针对IFNα的抗体慢性乙型肝炎慢性乙型肝炎在HBsAg血清清除过程中,这就是Peg-IFNα.

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