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香烟暴露对胎盘表观遗传学的影响:系统性审查

Raina D Pang¹, Sarah A Herman¹, Hannah Ruck¹

¹Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.

Reproductive toxicology (Elmsford, N.Y.)

|January 7, 2026

概括

怀孕期间吸烟会影响胎盘表观遗传学,影响胎儿的发育. 需要对非烟草烟草制品进行更多的研究.

科学领域:

产科和妇科产科和妇科
发展生物学发展生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

怀孕期间的烟草使用是产生不良分娩结果的重要可修改风险因素.
胎盘在调节胎儿生长,发育和整体妊娠健康方面发挥着至关重要的作用.
胎盘的表观遗传修饰对于正常的妊娠进展至关重要.

研究的目的:

系统地审查怀孕期间使用烟草制品对胎盘表观遗传学的影响.
探索烟草引起的胎盘表观基因组变化与孕产妇/胎儿健康结果之间的关联.

主要方法:

对20篇研究烟草使用和胎盘表观遗传学的论文进行系统审查.
分析的重点是研究CpG位点和/或基因中的甲基化变化.
大多数研究 (85%) 检查了满期的胎盘,所有研究都集中在可燃性香烟的吸烟上.

主要成果:

确定结合,催化活性和转录调节活性是胎盘基因中受影响的最常见的分子通路.
很大一部分受影响的基因无法被分配到特定的分子途径.
有证据表明,由于吸烟,胎盘表观遗传学发生了改变.

结论:

怀孕期间吸烟会改变胎盘表观遗传学,可能影响胎儿的发育.
需要进一步的研究来阐明特定的表观遗传机制和健康后果.
非烟草烟草产品对胎盘表观遗传学的影响在很大程度上是未知的,需要进行调查.

关键词:

通过DNA甲基化.胎盘胎盘胎盘胎盘胎盘表观遗传学胎盘表观遗传学怀孕怀孕怀孕怀孕怀孕吸烟是为了吸烟.烟草烟草的烟草烟草是一种烟草.

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