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Updated: Jan 13, 2026

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基因型驱动的lncRNA表达变异是导致高度血清性卵巢癌的根源

Mingming Lu1, Yanan Chu2, Ziwei Zhu3

  • 1Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang 310052, China; Liangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou, Zhejiang 311121, China; National Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China; China National Center for Bioinformation, Beijing 100101, China; Beijing Institute of Genomices, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Journal of advanced research
|January 7, 2026
PubMed
概括

这项研究揭示了长非编码RNAs (lncRNAs) 在高度血清性卵巢癌 (HGSOC) 易感性中发挥着重要作用,为早期检测和治疗提供了潜在的新途径. 影响lncRNA表达的遗传变异是HGSOC的关键驱动因素.

关键词:
在CRHR1-IT1中,在本地化,在本地化.卵巢癌是发生在卵巢中的癌症.我们的eQTL是eQTL.在ncRNA中,我们可以在GWAS之后.

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