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三龙通过铁死途径诱导Bombyx mori的生长和发育受损

Wen Zhang¹, Huang Lin¹, Ziqin Xiao¹

¹Jiangsu Key Laboratory of Sericultural and Animal Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, China; Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture and Rural Affairs, Sericultural Scientific Research Center, Chinese Academy of Agricultural Sciences, Zhenjiang, China.

Insect biochemistry and molecular biology

|January 7, 2026

概括

三 (TCF) 杀虫剂通过触发铁亡,一种细胞死亡途径,包括铁的积累和氧化应激,从而损害丝虫的生长. N-乙半氨酸 (NAC) 提供了部分保护,为大羊养殖行业提出了新的策略.

科学领域:

* 农业科学农业科学
* 毒理学毒理学毒理学
* 分子生物学 * 分子生物学

背景情况:

*有机农药三 (TCF) 对于作物保护至关重要,但对丝养殖行业构成风险.
*剩余的TCF对Bombyx mori (B. mori) 养殖产生负面影响,造成经济损失.
*TCF对丝虫的确切毒性作用和分子机制尚未完全理解.

研究的目的:

* 调查TCF诱导丝虫损伤的分子标和机制.
* 阐明铁死在TCF毒性的作用.
* 探索潜在的防护策略,防止TCF暴露.

主要方法:

* 结合体内和体外方法.
*利用RNA测序和qRT-PCR进行基因表达分析.
*评估了铁亡的细胞指标,包括铁含量和氧化应激.

主要成果:

*TCF暴露显著降低了丝虫的体重,增加了死亡率和发育障碍 (化,化,卵子生产).
*RNA测序揭示了差异性的基因表达,特别是LOC101744260和改变的谷氨酸代谢,与铁死有关.
*TCF增加了与铁亡相关的基因表达,细胞内铁和氧化应激,N-乙半氨酸 (NAC) 的作用部分逆转.

结论:

*TCF通过激活铁灭菌路径来诱导丝虫的生长和发育损伤.
* 这项研究为TCF在丝虫中的毒性机制提供了新的见解.
* 结果为管理大麻农业行业的农药污染提供了理论基础.

关键词:

波姆比克斯 (Bombyx mori mori mori) 是一个有趣的动物.铁化是铁化的一种.杀虫剂是一种杀虫剂.在RNA测序过程中,RNA测序三烯 (Trichlorfon) 是一种三烯化合物.

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