前列腺癌查在欧盟的过去和现在
J Gómez Rivas1, P Gómez Dávila2, A M Tarrazo Antelo3
1Servicio de Urología, Hospital Clínico San Carlos, Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Clínico San Carlos, Madrid, Spain; Facultad de Medicina, Universidad Complutense de Madrid, Spain.
Actas urologicas espanolas
|January 7, 2026
概括
使用前列腺特异抗原 (PSA) 测试进行前列腺癌查已经发展. 新兴的风险分层策略和新工具旨在实现更准确,更个性化的检测,减少过度诊断和过度治疗.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 诊断成像 诊断成像 诊断成像
- 生物标志物 生物标志物
背景情况:
- 通过前列腺特异性抗原 (PSA) 检测进行前列腺癌 (PCa) 查,可以提供早期检测,但也引起了人们对过度诊断和过度治疗的担忧.
- 本综述探讨了PCa查的历史发展,其挑战,以及精确,个性化检测的新方法.
研究的目的:
- 审查前列腺癌查策略的演变.
- 突出挑战和新兴方法,以准确和个性化的PCa检测.
- 讨论在PCa查中向个性化医疗的转变.
主要方法:
- 使用PubMed和谷歌学者进行了叙事文献审查.
- 关键词包括前列腺癌,查,过度诊断和相关的MeSH术语.
- 包括标准包括临床研究,系统审查和当前的指导方针.
主要成果:
- 前列腺特异性抗原 (PSA) 查试验 (PLCO,ERSPC,哥德堡) 显示对前列腺癌死亡率的不同影响.
- 建议转向风险分层查,整合MRI,生物标志物,风险计算器和AI等工具.
- 这些进步提高了诊断准确度,减少了不必要的活检,并专注于临床上重要的疾病.
结论:
- 前列腺癌查的未来在于个性化医学.
- 整合临床,成像和分子数据将提高查效率.
- 这种个性化的方法旨在尽量减少不必要的干预,并改善患者的治疗结果.
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