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在临床前模型中,光子闪光节省了辐射诱导的心脏功能变化,重塑和心律失常

Mihaela Ghita-Pettigrew1, Kathryn H Brown1, Brianna N Kerr1

  • 1Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Northern Ireland, UK.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
|January 7, 2026
PubMed
概括

与传统方法相比,FLASH辐射显著保护心脏免受辐射损伤. 这项研究表明,光子FLASH可以保持心脏功能和结构,减少治疗后纤维化和炎症.

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Clearance Models: Physiological Models01:09

Clearance Models: Physiological Models

Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's proficiency in drug...