在衰老过程中进行预测处理:有效连接的多个时间尺度
Martin Tom Banaschewski1, Christoph Mathys2, István Winkler3
1Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany.
The European journal of neuroscience
|January 7, 2026
概括
大脑通过在几秒钟和几分钟内调整神经连接来适应不断变化的声音. 衰老会影响这种适应,影响大脑如何预测和处理新的听觉信息.
科学领域:
- 神经科学是一个神经科学.
- 听觉感知是一种听觉感知.
- 认知老龄化 认知老龄化
背景情况:
- 预测处理理论通过自上而下的预测和自下而上的错误来解释感知.
- 神经连接的适应动态感官环境和衰老效应尚未完全理解.
研究的目的:
- 研究时间因素 (秒,分钟) 和年龄如何影响神经反应和对不断变化的听觉刺激的连接.
- 检查神经适应的动态在不同的时间尺度和年龄组.
主要方法:
- 记录了63名参与者 (18-75岁) 的脑电图 (EEG) 听取听觉序列.
- 分析了与事件相关的潜力 (ERP) 并使用动态因果建模 (DCM) 来推断有效的连接性.
主要成果:
- 对于原始偏差,ERP比反向偏差更大.
- 神经响应幅度随时间尺度和年龄而变化,在几秒内增加,但在几分钟和年龄下降.
- DCM显示了偏差的上下连接性增加,内在连接性的时间尺度依赖的变化.
- 老化改变了通过偏差类型和缓慢动态来调节连接.
结论:
- 大脑在多个时间范围内动态地适应不断变化的感官环境.
- 衰老与神经适应和预测处理动态的特定变化有关.
更多相关视频
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
15.6K
14:57Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
95.1K
相关概念视频
Cognitive Development During Adulthood
768
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
768
Information Processing Approach
508
The information-processing theory of cognitive development centers on fundamental mental processes, including attention, memory, and problem-solving skills. Researchers in this field examine how cognitive abilities, such as working memory, evolve and influence children's overall development. Studies indicate that children with stronger working memory tend to excel in reading comprehension, math, and problem-solving compared to peers with less efficient memory skills. Low working memory is...
508
Aging
580
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
580
Neuroplasticity
1.6K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
1.6K
Parallel Processing
626
The brain processes sensory information rapidly due to parallel processing, which involves sending data across multiple neural pathways at the same time. This method allows the brain to manage various sensory qualities, such as shapes, colors, movements, and locations, all concurrently. For instance, when observing a forest landscape, the brain simultaneously processes the movement of leaves, the shapes of trees, the depth between them, and the various shades of green. This enables a quick and...
626
Long-term Potentiation
58.2K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
58.2K
