异构体组织的异构体结构概况跨血管苗,它们与蛋白质域的关系,以及功能上的含义
Taikui Zhang1,2, Lin Zhang3, Hong Ma4
1Co-Innovation Center for Sustainable Forestry in Southern China, State Key Laboratory of Tree Genetics and Breeding, College of Life Sciences, Nanjing Forestry University, Nanjing, Jiangsu, China.
Nature communications
|January 7, 2026
概括
大多数真核基因都含有微型和小型外原体,在种子植物中发现的外原体结构是保存的. 这表明通过替代拼接来调节蛋白质功能的保存机制.
科学领域:
- 基因组学就是基因组学.
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 细胞基因编码蛋白质,并具有多种异构体大小,包括微型和小型类别.
- 全基因组对血管种子中外子-内子组织和保护的分析仍然未得到充分探索.
研究的目的:
- 为了研究全基因组的外子-内子组织和在血管精子中保存.
- 分析domain-exon对应及其对蛋白质功能调节的影响.
主要方法:
- 对46种生殖精子和4种生殖精子中外子-内子结构的比较基因组学分析.
- 开发和应用一种新的生物信息工具ExonEvo,用于外子-内子结构比较.
- 检查同源基因中的域-外显子对应.
主要成果:
- 大约35%的外显子是微型和小型的,影响大多数基因;其他被归类为中型,大型或超级外显子.
- 在同源基因中,大约69%的被保存的外基因在主要的血管苗子组中共享,在所有种子植物中大约47%被保存.
- 大多数保存的蛋白质域与多个保存的外形子家族相对应,外形子的替代拼接似乎是一个保存的调节机制.
结论:
- 这项研究提供了种子植物中外显子结构和域外显子组织的原生态景观.
- 保存的外因子结构及其与蛋白质域的关系支持基因和蛋白质功能的转录后调节模型.
相关概念视频
Evolutionary Relationships through Genome Comparisons
6.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.8K
Organization of Genes
73.0K
Overview
73.0K
Exon Recombination
4.1K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon...
Exon shuffling follows “splice frame rules.” Each exon...
4.1K
Conservation of Protein Domains Over Different Proteins
14.0K
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
14.0K
Protein Families
16.6K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key...
16.6K
Protein Families
4.2K
4.2K


