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Updated: Jun 30, 2026

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
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药物和单细胞基因表达的整合识别了敏感和耐药的质母细胞瘤细胞群

Robert K Suter1, Anna M Jermakowicz2, Rithvik Veeramachaneni2

  • 1Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. RKS82@Georgetown.edu.

Nature communications
|January 7, 2026
PubMed
概括

质母细胞瘤 (GBM) 药物发现得到了scFOCAL的推进,scFOCAL是一个预测细胞状态药物反应的新平台. 这确定了一种新的组合疗法来治疗这种致命的大脑癌症.

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Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...