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Updated: Jan 13, 2026

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活性化物通过瘤微环境中的代谢变化加速CD8+ T细胞耗尽

Yasuharu Haku1,2, Koji Kitaoka1, Koki Ichimaru1,3

  • 1Department of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Nature immunology
|January 7, 2026
PubMed
概括

活性化物损害了CD8+ T细胞中的线粒体脂肪酸氧化 (FAO),促进了疲劳. 抑制化物或脂质过氧化可以通过恢复代谢平衡来增强抗瘤免疫力.

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