Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Targeting androgen receptor transcriptionally represses VCP and enhances the efficacy of oncolytic-immunotherapy in hepatocellular carcinoma.

Pharmacological research·2026
Same author

Scavenger-controlled activation of lignin in microwave-assisted deep eutectic solvents for antioxidant nanoparticles.

Bioresource technology·2026
Same author

Efficient DNA Extraction Coupled with Fluorescence Loop-Mediated Isothermal Amplification (LAMP) for On-Site Early Warning Detection of Vibrio parahaemolyticus.

Marine biotechnology (New York, N.Y.)·2026
Same author

Real-world evaluation of online visual acuity self-testing and remote consultation: three years of implementation experience in a paediatric ophthalmology service.

Eye (London, England)·2026
Same author

Targeting DOT1L Reactivates HERV-K to Drive Cell-Autonomous and Paracrine Senescence in Adenocarcinoma of the Esophagogastric Junction.

Cancer research·2026
Same author

Real-World Performance of a New Online Eye Symptom Triage Tool (Eye+Dot) in an Emergency Eye Clinic: Mixed Methods Evaluation Study.

JMIR human factors·2026

相关实验视频

Updated: Jan 13, 2026

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy
07:33

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

Published on: September 19, 2025

730

工程外膜囊泡增强固体瘤CAR-T细胞疗法

Xianjun Li1,2,3, Xuehan Li1,4, Jiaqi Shi1,5

  • 1Heilongjiang Province Key Laboratory of Molecular Oncology, Harbin, China.

Nature biomedical engineering
|January 7, 2026
PubMed
概括

研究人员开发了一种细菌外膜囊泡 (OMV) 平台,以改善固体瘤的仿真抗原受体 (CAR) -T细胞疗法. 这种方法可以逆转免疫抑制,并提高CAR-T细胞对异质瘤的有效性.

更多相关视频

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
06:10

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

889
Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy
09:12

Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy

Published on: June 14, 2024

1.4K

相关实验视频

Last Updated: Jan 13, 2026

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy
07:33

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

Published on: September 19, 2025

730
Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
06:10

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

889
Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy
09:12

Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy

Published on: June 14, 2024

1.4K

科学领域:

  • 免疫学 免疫学 免疫学
  • 生物技术是生物技术.
  • 在瘤学瘤学.

背景情况:

  • 化学抗原受体 (CAR) -T细胞疗法在固体瘤中面临挑战,包括免疫抑制瘤微环境和可变抗原表达.
  • 细菌外膜囊泡 (OMVs) 是免疫调节的,适合于工程制造的药物输送.

研究的目的:

  • 开发一种基于细菌OMV的平台,BROAD-CAR,用于逆转免疫抑制并优化固体瘤的CAR-T细胞疗法中的抗原呈现.
  • 通过向PD-1/PD-L1通路和修改瘤抗原来增强CAR-T细胞的抗瘤活性和扩张.

主要方法:

  • 工程化细菌外膜囊泡 (OMVs) 来表达抗PD-L1抗体并为CARs提供向抗原等离子体.
  • 利用BROAD-CAR平台阻止PD-1/PD-L1信号传输并在现场修改瘤抗原.
  • 在试验室和体内乳腺癌小鼠模型中评估了BROAD-CAR与CAR-T细胞结合的疗效.

主要成果:

  • BROAD-CAR平台有效地阻断了PD-1/PD-L1信号通路,增强了CAR-T细胞的抗瘤活性和增殖.
  • BROAD-CAR改善了免疫抑制瘤微环境,从而改善了CAR-T细胞的扩张.
  • 该平台促进了局部瘤抗原修饰,使抗原异质和抗原阴性瘤的CAR-T细胞介导溶解成为可能,并抑制了复发和转移.

结论:

  • 基于细菌OMV的BROAD-CAR平台提供了一种安全有效的策略,以克服CAR-T细胞治疗在固体瘤中的关键局限性.
  • 这种方法提高了CAR-T细胞的疗效,并扩大了适用性,特别是在抗原异质和抗原阴性固体瘤中.
  • BROAD-CAR代表了改善CAR-T细胞治疗结果在具有挑战性的固体瘤环境中的有希望的进步.