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双向CRISPR屏幕解码一个GLIS3依赖的纤维细胞电路

Vladislav Pokatayev ^1,2,3, Alok Jaiswal ^2,3, Angela R Shih ⁴

¹Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
²Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
³Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁴Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
⁵Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁶Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. dgraham@broadinstitute.org.
⁷Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. dgraham@broadinstitute.org.
⁸Broad Institute of MIT and Harvard, Cambridge, MA, USA. dgraham@broadinstitute.org.
⁹Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. dgraham@broadinstitute.org.
¹⁰Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA, USA. dgraham@broadinstitute.org.
¹¹Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.
¹²Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.
¹³Broad Institute of MIT and Harvard, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.
¹⁴Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.
¹⁵Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.

⁰Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Nature +

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2026年一月7日

概括

No abstract available on PubMed