高血压的精准营养:茶,咖啡,抗氧化剂维生素与多基因风险的相互作用在多民族人群中
Haeng Jeon Hur1, Hye Jeong Yang1, Min Jung Kim1
1Precision Nutrition Research Group, Korea Food Research Institute, Wanju, Jeollabuk-do, Republic of Korea.
European journal of clinical nutrition
|January 7, 2026
概括
遗传变异在不同人群中影响高血压风险,通过不同的途径起作用. 有针对性的营养摄入量可以减轻这种遗传风险,为预防高血压的基因知情饮食策略铺平道路.
科学领域:
- 遗传学和精准医学 遗传学和精准医学
- 营养流行病学 营养流行病学
- 心血管疾病研究研究
背景情况:
- 高血压是一种复杂的疾病,受遗传倾向和饮食习惯的影响.
- 了解基因与饮食之间的相互作用对于制定针对高血压的个性化预防策略至关重要.
研究的目的:
- 确定与韩国和英国人群中高血压相关的遗传变异.
- 研究与高血压风险相关的已识别的遗传变异和营养摄入量之间的相互作用.
主要方法:
- 在韩国基因组和流行病学研究 (KoGES) 和英国生物银行 (UKBB) 中,对高血压进行了全基因组关联分析.
- 基因风险评分 (GRS) 是使用显著单核酸多态 (SNP) 构建的.
- 后勤回归模型被用来分析基因饮食相互作用.
主要成果:
- 像FGF5,CYP17A1和ATP2B1这样的基因中的几种常见SNP在两个队列中都与高血压有显著的关联.
- 不同的生物通路,包括脂质和血管信号,在韩国人和高加索人身上都存在.
- 6-SNP遗传风险得分与高血压有关,但在低GRS患者中,高茶和咖啡摄入量减轻了这种风险.
- 在KoGES队列中,RGL3 rs167479变体与维生素C,D,B12和黄类药物发生了显著的相互作用.
结论:
- 常见的遗传变异通过不同种群的多样化分子途径导致高血压.
- 饮食干预措施,特别是有针对性的营养摄入量,显示出减轻遗传影响高血压风险的潜力.
- 这些发现支持开发基因信息的饮食策略,以有效预防高血压.
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