通过连接体扩散和传输模型推进空间细胞通信推断
Jiating Yu1, Jinyue Zhao2, Tao Ren3,4
1School of Mathematics and Statistics, Nanjing University of Information Science & Technology, Nanjing, China.
Communications biology
|January 7, 2026
概括
SCILD通过使用一种新的连接物扩散模型,以单细胞分辨率推断空间细胞通信. 这个工具准确地捕捉复杂的信号动态,并预测目标基因,推进空间转录学研究.
科学领域:
- 分子生物学分子生物学
- 系统生物学 系统生物学
- 生物信息学是一种生物信息学.
背景情况:
- 细胞-细胞通信对于多细胞生物来说至关重要,依赖于连接体-受体相互作用.
- 传统的研究细胞通信的方法缺乏空间分辨率,容易出现错误.
- 空间转录学能够通过精确的空间信息来分析通信事件.
研究的目的:
- 开发一种新的计算框架,以单细胞分辨率推断空间细胞通信.
- 整合联体扩散,竞争性结合和运输动态到一个统一的模型中.
- 为了预测由联体受体相互作用调节的下游目标基因.
主要方法:
- 推出了基于优化的框架SCILD (空间细胞通信推理与联结体扩散和传输模型).
- 模拟蜂通信作为一个带有潜在损失的货物运输系统,包括连接体扩散和竞争性结合.
- 利用神经网络建模和in silico扰动用于目标基因预测.
主要成果:
- 在单个细胞层面上,SCILD准确地捕捉了竞争性的沟通动态.
- 确定了生物相关的联体受体标志物,驱动域特异信号.
- 解决了子域特定的通信模式和强有力的预测目标基因.
- 与外部数据库对比的验证结果.
结论:
- SCILD是一个多功能和强大的工具,用于空间细胞通信研究.
- 该框架增强了对复杂生物系统中细胞-细胞信号传递的理解.
- SCILD提供了以前无法实现的通信动态的高分辨率洞察力.
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