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Updated: Jan 13, 2026

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions
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Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

Published on: April 21, 2016

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蛋白质与蛋白质相互作用塑造了遗传变异对蛋白质表达和复杂特征的跨调节性影响

Jinghui Li1, Yang I Li1,2,3, Xuanyao Liu4,5

  • 1Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.

Nature genetics
|January 7, 2026
PubMed
概括

与复杂特征相关的遗传变异通常会影响基因调节. 这项研究表明,参与蛋白质-蛋白质相互作用 (PPI) 的跨蛋白质定量特征位点 (pQTLs) 有助于解释全基因组关联研究 (GWAS) 位点并确定治疗点.

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